Central Nervous System Malignancies: What Next?

Central nervous system malignancies: what next?

One of the most devastating malignancies afflicting man is that of cancer in the central nervous system (CNS). Although that diagnosis in U.S. Senator Ted Kennedy raised its profile, the disease has largely hovered in the background—a predictable result of therapeutic disappointment. It is a disease whose outcomehas not been substantially altered in 30 years, despite newmolecular discoveries an...

burden of the central nervous system malignancies in iran 2003

abstract objective : the policy makers and social managers need some criteria for building up the appropriate health status of the community and observe the equity and equality on it. they have to know the burden of diseases as a main determining factor for decision making, planning and programming. disability adjusted life years (dalys) is a criteria which shows the wasted life time due to ear...

ADENOSINE IN THE CENTRAL NERVOUS SYSTEM

Besides being a metabolite of nucleotides like ATP, adenosine is a mediator of neuronal function in the central nervous system. Its actions are mediated by at least three extracellular receptors. In this review different aspects of adenosine such as biosynthesis, release, inactivation and its receptors are discussed. It also covers pre- and postsynaptic effects as well as postreceptor mecha...

Modulation of Tumor Tolerance in Primary Central Nervous System Malignancies

Central nervous system tumors take advantage of the unique immunology of the CNS and develop exquisitely complex stromal networks that promote growth despite the presence of antigen-presenting cells and tumor-infiltrating lymphocytes. It is precisely this immunological paradox that is essential to the survival of the tumor. We review the evidence for functional CNS immune privilege and the impa...

Congress Report: Trends in Central Nervous System Malignancies